IV0136 InVivoPro Anti-Mouse IL-23 (p19) in vivo antibody, Clone G23-8_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

IL-23 is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages. IL-23 has been shown to enhance IFNγ production by memory T cells. Additionally, mouse IL-23 induces the proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Mouse IL-23 (but not IL-12) can also activate mouse memory T cells to produce the potent proinflammatory cytokine IL-17. IL-23 has been shown to be upregulated in certain autoimmune diseases and promote immunity in response to some viral and mycobacterial infections.

Specifications

Catalog	IV0136
Product Name	InVivoPro Anti-Mouse IL-23 (p19) in vivo antibody, Clone G23-8
Size	1mg/5mg/25mg/50mg/100mg
Isotype	Rat IgG1 κ
Clone	G23-8
Target	IL-23 (p19)
Other Names	IL-23 subunit alpha, IL-23-A, IL-23p19, Il23a, Interleukin-23 subunit alpha, Interleukin-23 subunit p19
Isotype Control Catalog Code	Rat IgG1 Isotype Control
Dilution Buffer	PBS, pH 7.2, contains no stabilizers or preservatives
Reactivity	Mouse
Host Species	Rat
How much antibody to use in vivo	Each investigator should determine their own optimal working dilution for specific applications.
Background	IL-23 is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages. IL-23 has been shown to enhance IFNγ production by memory T cells. Additionally, mouse IL-23 induces the proliferation of memory T cells (but not naive T cells), whereas IL-12 has no effect on memory cells. Mouse IL-23 (but not IL-12) can also activate mouse memory T cells to produce the potent proinflammatory cytokine IL-17. IL-23 has been shown to be upregulated in certain autoimmune diseases and promote immunity in response to some viral and mycobacterial infections.
Applications	in vivo IL-23p19 neutralization
Purification	protein A or G
Storage	This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.
Shipping	2-8°C with blue ice
Concentration	Lot specific, generally ≥ 5.0 mg/ml
Shelf Life	12 months from the date of receipt if stored as recommended
Formulation	PBS, pH 7.2, contains no stabilizers or preservatives
Sterility	0.2 μM filtered
Endotoxin	≤ 1.0 EU/mg, by the LAL method
Purity	99%