IV0100 InVivoPro Anti-Mouse PD-1(CD279) in vivo antibody, Clone RMP1-14_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

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Cat. Number

IV0100

Chemical Name

IV0100 InVivoPro Anti-Mouse PD-1(CD279) in vivo antibody, Clone RMP1-14

Qty 1

5mg

Qty 2

50mg

Application Notes

99%

References

Product Details

CD279, also known as programmed death-1 (PD-1) is a 50-55 kD immunoglobulin superfamily member. PD-1 is expressed on a subset of CD4-CD8- thymocytes, and on activated T and B cells. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. This RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production.

Specifications

Catalog	IV0100
Product Name	InVivoPro Anti-Mouse PD-1(CD279) in vivo antibody, Clone RMP1-14
Size	1mg/5mg/25mg/50mg/100mg
Isotype	Rat IgG2a κ
Clone	RMP1-14
Target	PD-1
Other Names	Programmed Death-1, CD279, PD-1
Isotype Control Catalog Code	IV0105 or Rat IgG2a Isotype Control
Dilution Buffer	PBS, pH 7.2, contains no stabilizers or preservatives
Reactivity	Mouse
Host Species	Rat
How much antibody to use in vivo	200-500 μg per mouse; or 10 mg/kg. This range is based off the most recent publication data using the RMP1-14 clone in vivo. Each investigator should determine their own optimal working dilution for specific applications.
Background	CD279, also known as programmed death-1 (PD-1) is a 50-55 kD immunoglobulin superfamily member. PD-1 is expressed on a subset of CD4-CD8- thymocytes, and on activated T and B cells. The PD-1 ligands, PD-L1 (also known as B7-H1) and PD-L2 (B7-DC), are members of the B7 immunoglobulin superfamily. This RMP1-14 antibody has been reported to block the binding of PD-1 to its ligands (B7-H1 and B7-DC) and to inhibit T cell proliferation and cytokine production.
Applications	In vivo blocking of PD-1/PD-L1 signaling
Purification	protein A or G
Storage	This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.
Shipping	2-8°C with blue ice
Concentration	Lot specific, generally ≥ 5.0 mg/ml
Shelf Life	12 months from the date of receipt if stored as recommended
Formulation	PBS Buffer, PH 7.2, with no carrier protein, or preservatives.
Sterility	0.2 μM filtered
Endotoxin	≤ 1.0 EU/mg, by the LAL method
Purity	99%