IV0109 InVivoPro Anti-Mouse CTLA-4 (CD152) in vivo antibody, Clone 9D9_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

CTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. CTLA-4 has therapeutic potential both as an agonist to reduce immune activity, and an antagonist to increase immune activity.

Specifications

Catalog	IV0109
Product Name	InVivoPro Anti-Mouse CTLA-4 (CD152) in vivo antibody, Clone 9D9
Size	1mg/5mg/25mg/50mg/100mg
Isotype	Mouse IgG2b
Clone	9D9
Target	CTLA-4
Other Names	CD152, Cytotoxic T Lymphocyte-Associated Antigen-4, Ly-56
Isotype Control Catalog Code	Mouse IgG2b Isotype Control
Dilution Buffer	PBS, pH 7.2, contains no stabilizers or preservatives
Reactivity	Mouse
Host Species	Mouse
How much antibody to use in vivo	200-500 μg per mouse; or 10-20 mg/kg. This range is based off the most recent publication data using the 9D9 clone in vivo. Each investigator should determine their own optimal working dilution for specific applications.
Background	CTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. CTLA-4 has therapeutic potential both as an agonist to reduce immune activity, and an antagonist to increase immune activity.
Applications	In vivo CTLA-4 neutralization, Western blot
Purification	protein A or G
Storage	This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.
Shipping	2-8°C with blue ice
Concentration	Lot specific, generally ≥ 5.0 mg/ml
Shelf Life	12 months from the date of receipt if stored as recommended
Formulation	PBS Buffer, PH 7.2, with no carrier protein, or preservatives.
Sterility	0.2 μM filtered
Endotoxin	≤ 1.0 EU/mg, by the LAL method
Purity	99%