您的位置:首页>>生命科学>>抗原/抗体>>IV0109 InVivoPro Anti-Mouse CTLA-4 (CD152) in vivo antibody, Clone 9D9
Cat. Number
IV0109
Chemical Name
IV0109 InVivoPro Anti-Mouse CTLA-4 (CD152) in vivo antibody, Clone 9D9
References

Catalog: IV0109

Cost advantage to: BE0164

Clone: 9D9

Isotype: Mouse IgG2b

Citations of the same Clone: 152

Product Details

CTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. CTLA-4 has therapeutic potential both as an agonist to reduce immune activity, and an antagonist to increase immune activity.

Specifications

CatalogIV0109
Product NameInVivoPro Anti-Mouse CTLA-4 (CD152) in vivo antibody, Clone 9D9
Size1mg/5mg/25mg/50mg/100mg
IsotypeMouse IgG2b
Clone9D9
TargetCTLA-4
Other NamesCD152, Cytotoxic T Lymphocyte-Associated Antigen-4, Ly-56
Isotype Control Catalog CodeMouse IgG2b Isotype Control
Dilution BufferPBS, pH 7.2, contains no stabilizers or preservatives
ReactivityMouse
Host SpeciesMouse
How much antibody to use in vivo200-500 μg per mouse; or 10-20 mg/kg. This range is based off the most recent publication data using the 9D9 clone in vivo. Each investigator should  determine their own optimal working dilution for specific applications.
BackgroundCTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. CTLA-4 has therapeutic potential both as an agonist to reduce immune activity, and an antagonist to increase immune activity.
ApplicationsIn vivo CTLA-4 neutralization, Western blot
Purificationprotein A or G
StorageThis antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.
Shipping2-8°C with blue ice
ConcentrationLot specific, generally ≥ 5.0 mg/ml
Shelf Life12 months from the date of receipt if stored as recommended
FormulationPBS Buffer, PH 7.2, with no carrier protein, or preservatives.
Sterility0.2 μM filtered
Endotoxin≤ 1.0 EU/mg, by the LAL method
Purity99%

I

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