IV0107 InVivoPro Anti-Mouse PD-1(CD279) in vivo antibody, Clone 29F.1A12_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

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Cat. Number

IV0107

Chemical Name

IV0107 InVivoPro Anti-Mouse PD-1(CD279) in vivo antibody, Clone 29F.1A12

Qty 1

5mg

Qty 2

50mg

Application Notes

99%

References

Catalog: IV0107

Cost advantage to: BE0273

Clone: 29F.1A12

Isotype: Rat IgG2a

Citations of the same Clone: 131

Product Details

Programmed death-1 (PD-1), also know as CD279 is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Like the clones RMP1-14 and J43 antibodies, the 29F.1A12 antibody has been shown to block the binding of PD-1 to its ligands in vivo.

Specifications

Catalog	IV0107
Product Name	InVivoPro Anti-Mouse PD-1(CD279) in vivo antibody, Clone 29F.1A12
Size	1mg/5mg/25mg/50mg/100mg
Isotype	Rat IgG2a
Clone	29F.1A12
Target	PD-1
Other Names	Programmed Death-1, CD279, PD-1
Isotype Control Catalog Code	IV0105 or Rat IgG2a Isotype Control
Dilution Buffer	PBS, pH 7.2, contains no stabilizers or preservatives
Reactivity	Mouse
Host Species	Rat
How much antibody to use in vivo	200-500 μg per mouse; or 10 mg/kg. This range is based off the most recent publication data using the 29F.1A12 clone in vivo. Each investigator should determine their own optimal working dilution for specific applications.
Background	Programmed death-1 (PD-1), also know as CD279 is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is transiently expressed on CD4 and CD8 thymocytes as well as activated T and B lymphocytes and myeloid cells. Like the clones RMP1-14 and J43 antibodies, the 29F.1A12 antibody has been shown to block the binding of PD-1 to its ligands in vivo.
Applications	In vivo blocking of PD-1/PD-L signaling, Flow cytometry, Immunohistochemistry(Frozen), Western blot
Purification	protein A or G
Storage	This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.
Shipping	2-8°C with blue ice
Concentration	Lot specific, generally ≥ 5.0 mg/ml
Shelf Life	12 months from the date of receipt if stored as recommended
Formulation	PBS Buffer, PH 7.2, with no carrier protein, or preservatives.
Sterility	0.2 μM filtered
Endotoxin	≤ 1.0 EU/mg, by the LAL method
Purity	99%