IV0110 InVivoPro Anti-Mouse TNFα in vivo antibody, Clone TN3-19.12_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

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Cat. Number

IV0110

Chemical Name

IV0110 InVivoPro Anti-Mouse TNFα in vivo antibody, Clone TN3-19.12

Qty 1

5mg

Qty 2

50mg

Application Notes

99%

References

Catalog: IV0110

Cost advantage to: BE0058

Clone: TN3-19.12

Isotype: Armenian Hamster IgG

Citations of the same Clone: 12

Product Details

The tumor necrosis factor (TNF-alpha) is a multifaceted polypeptide cytokine known as a mediator of inflammation and immunity. It may mediate some of the significant changes in cellular homeostasis which accompany the invasion of the mammalian host by viruses, bacteria, and parasites. TNF-alpha is an acute phase protein which initiates a cascade of cytokines and increases vascular permeability, thereby recruiting macrophage and neutrophils to a site of infection. TNF-alpha secreted by the macrophage causes blood clotting which serves to contain the infection. TNF-alpha has been detected in synovial fluid of patients with rheumatoid arthritis. Clone TN3-19.12 antibody can neutralize the bioactivity of natural or recombinant TNF-alpha.

Specifications

Catalog	IV0110
Product Name	InVivoPro Anti-Mouse TNFα in vivo antibody, Clone TN3-19.12
Size	1mg/5mg/25mg/50mg/100mg
Isotype	Armenian Hamster IgG
Clone	TN3-19.12
Target	TNFα
Other Names	TNF-alpha, TNFSF2, Tnlg1f
Isotype Control Catalog Code	Armenian Hamster IgG Isotype Control
Dilution Buffer	PBS, pH 7.2, contains no stabilizers or preservatives
Reactivity	Mouse
Host Species	Armenian Hamster
How much antibody to use in vivo	200-500 μg per mouse; or 10-20 mg/kg. This range is based off the most recent publication data using the TN3-19.12 clone in vivo. Each investigator should determine their own optimal working dilution for specific applications.
Background	The tumor necrosis factor (TNF-alpha) is a multifaceted polypeptide cytokine known as a mediator of inflammation and immunity. It may mediate some of the significant changes in cellular homeostasis which accompany the invasion of the mammalian host by viruses, bacteria, and parasites. TNF-alpha is an acute phase protein which initiates a cascade of cytokines and increases vascular permeability, thereby recruiting macrophage and neutrophils to a site of infection. TNF-alpha secreted by the macrophage causes blood clotting which serves to contain the infection. TNF-alpha has been detected in synovial fluid of patients with rheumatoid arthritis. Clone TN3-19.12 antibody can neutralize the bioactivity of natural or recombinant TNF-alpha.
Applications	In vivo TNFα neutralization, Enzyme-linked Immunosorbent Assay
Purification	protein A or G
Storage	This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.
Shipping	2-8°C with blue ice
Concentration	Lot specific, generally ≥ 5.0 mg/ml
Shelf Life	12 months from the date of receipt if stored as recommended
Formulation	PBS Buffer, PH 7.2, with no carrier protein, or preservatives.
Sterility	0.2 μM filtered
Endotoxin	≤ 1.0 EU/mg, by the LAL method
Purity	99%