IV0112 InVivoPro Anti-Mouse CTLA-4 (CD152) in vivo antibody, Clone 9H10_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

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Cat. Number

IV0112

Chemical Name

IV0112 InVivoPro Anti-Mouse CTLA-4 (CD152) in vivo antibody, Clone 9H10

Qty 1

5mg

Qty 2

50mg

Application Notes

99%

References

Product Details

CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) also known as CD152, is a protein which is expressed on the surface of Helper T cells and plays an important regulatory role in the immune system. CTLA4 is a member of the immunoglobulin superfamily, expressed on the surface of Helper T cells. CTLA4 transmits an inhibitory signal to T cells. CTLA4 is potentially therapeutic in auto-immune diseases4, such as rheumatoid arthritis, HIV, autoimmune thyroid disease, multiple sclerosis and may also be useful during organ transplantation and cancer treatment. Clone 9H10 antibody has been shown to promote T cell co-stimulation by blocking CTLA4 binding, allowing for CD28 binding.

Specifications

Catalog	IV0112
Product Name	InVivoPro Anti-Mouse CTLA-4 (CD152) in vivo antibody, Clone 9H10
Size	1mg/5mg/25mg/50mg/100mg
Isotype	Syrian hamster IgG
Clone	9H10
Target	CTLA-4
Other Names	cytotoxic T-lymphocyte antigen 4, CTLA-4, CD152
Isotype Control Catalog Code	Syrian hamster lgG Isotype Control
Dilution Buffer	PBS, pH 7.2, contains no stabilizers or preservatives
Reactivity	Mouse
Host Species	Syrian hamster
How much antibody to use in vivo	200-300 μg per mouse; or 10-15 mg/kg. This range is based off the most recent publication data using the 9H10 clone in vivo. Each investigator should determine their own optimal working dilution for specific applications.
Background	CTLA4 (Cytotoxic T-Lymphocyte Antigen 4) also known as CD152, is a protein which is expressed on the surface of Helper T cells and plays an important regulatory role in the immune system. CTLA4 is a member of the immunoglobulin superfamily, expressed on the surface of Helper T cells. CTLA4 transmits an inhibitory signal to T cells. CTLA4 is potentially therapeutic in auto-immune diseases4, such as rheumatoid arthritis, HIV, autoimmune thyroid disease, multiple sclerosis and may also be useful during organ transplantation and cancer treatment. Clone 9H10 antibody has been shown to promote T cell co-stimulation by blocking CTLA4 binding, allowing for CD28 binding.
Applications	In vivo CTLA-4 neutralization
Purification	protein A or G
Storage	This antibody is stable for at least 2 months when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C or -80°C. Avoid repeated freeze thaw cycles.
Shipping	2-8°C with blue ice
Concentration	Lot specific, generally ≥ 5.0 mg/ml
Shelf Life	12 months from the date of receipt if stored as recommended
Formulation	PBS Buffer, PH 7.2, with no carrier protein, or preservatives.
Sterility	0.2 μM filtered
Endotoxin	≤ 1.0 EU/mg, by the LAL method
Purity	99%