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021-60498804
| Cat. Number | 066172295059694 |
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| Chemical Name | COX Fluorescent Inhibitor Screening Assay Kit |
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| References |
Background ReadingXie, W., Chipman, J.G., Robertson, D.L., et al. Expression of a mitogen- Kargman, S., Wong, E., Greig, G.M., et al. Mechanism of selective inhibition of human prostaglandin G/H synthase- Smith, C.J., Zhang, Y., Koboldt, C.M., et al. Pharmacological analysis of cyclooxygenase- Nugteren, D.H., and Hazelhof, E. Isolation and properties of intermediates in prostaglandin biosynthesis. Biochim Biophys Acta 326 448-461 (1973). Hamberg, M., and Samuelsson, B. Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis. Proc Natl Acad Sci USA 70 899-903 (1973). Blobaum, A.L., and Marnett, L.J. Structural and functional basis of cyclooxygenase inhibition. J Med Chem 50(7) 1425-1441 (2007). Jang, M., Cai, L., Udeani, G.O., et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275 218-220 (1997). Show all 7 Hide all but first 3
Description
Cyclooxygenase (COX, also called Prostaglandin H Synthase or PGHS) is a bifunctional enzyme exhibiting both COX and peroxidase activities. The COX component converts arachidonic acid to a hydroperoxy endoperoxide (PGG2), and the peroxidase component reduces the endoperoxide to the corresponding alcohol (PGH2), the precursor of PGs, thromboxanes, and prostacyclins.1,2 It is now well established that there are two distinct isoforms of COX, COX-
1 Nugteren, D.H., and Hazelhof, E. Isolation and properties of intermediates in prostaglandin biosynthesis. Biochim Biophys Acta 326 448-461 (1973). 2 Hamberg, M., and Samuelsson, B. Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis. Proc Natl Acad Sci USA 70 899-903 (1973). |
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