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| Cat. Number | 066078375068562 |
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| Chemical Name | HDAC1 Inhibitor Screening Assay Kit |
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| References |
Background ReadingGrunstein, M. Histone acetylation in chromatin structure and transcription. Nature 389 349-352 (1997 Sep 25). Suenaga, M., Soda, H., Oka, M., et al. Histone deacetylase inhibitors suppress telomerase reverse transcriptase mRNA expression in prostate cancer cells. Int J Cancer 97 621-625 (2002 Jan 1). Johnstone, R.W. Histone- Kwon, H.J., Kim, M.S., Kim, M.J., et al. Histone deacetylase inhibitor FK228 inhibits tumor angiogenesis. Int J Cancer 97 290-296 (2002 Jan 1). Strahl, B.D., and Allis, D. The language of covalent histone modifications. Nature 403 41-45 (2000 Jan 6). Cheung, W.L., Briggs, D.B., and Allis, C.D. Acetylation and chromosomal functions. Curr Opin Cell Biol 12 326-333 (2000 Jan 1). Show all 6 Hide all but first 3
Description
Histone deacetylases (HDACs) catalyze the hydrolytic removal of acetyl groups from histone lysine residues resulting in chromatin condensation and transcriptional repression of chromosomal DNA. Thus, HDAC inhibition allows the conformation of DNA to be relaxed and transcriptional activation to ensue. Changes in the transcription of key genes have linked HDAC inhibitors to blocking angiogenesis and cell cycling, and promoting apoptosis and differentiation. Cayman’s HDAC1 Inhibitor Screening Assay Kit provides a fast, fluorescence-
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