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| Cat. Number | 066074868659506 |
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| Chemical Name | HDAC8 Inhibitor Screening Assay Kit |
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| References |
Background ReadingPan, L., Lu, J., and Huang, B. HDAC inhibitors: A potential new category of anti- Yang, X., and Seto, E. The Rpd3/Hda1 family of lysine deacetylases: From bacteria and yeast to mice and men. Nat Rev Mol Cell Biol 9(3) 206-213 (2008). Oehme, I., Deubzer, H.E., Wegener, D., et al. Histone deacetylase 8 in neuroblastoma tumorigenesis. Clin Cancer Res 15(1) 91-99 (2009). Grunstein, M. Histone acetylation in chromatin structure and transcription. Nature 389 349-352 (1997 Sep 25). Strahl, B.D., and Allis, D. The language of covalent histone modifications. Nature 403 41-45 (2000 Jan 6). Cheung, W.L., Briggs, D.B., and Allis, C.D. Acetylation and chromosomal functions. Curr Opin Cell Biol 12 326-333 (2000 Jan 1). Kwon, H.J., Kim, M.S., Kim, M.J., et al. Histone deacetylase inhibitor FK228 inhibits tumor angiogenesis. Int J Cancer 97 290-296 (2002 Jan 1). Suenaga, M., Soda, H., Oka, M., et al. Histone deacetylase inhibitors suppress telomerase reverse transcriptase mRNA expression in prostate cancer cells. Int J Cancer 97 621-625 (2002 Jan 1). Johnstone, R.W. Histone- Hu, E., Chen, Z., Fredrickson, T., et al. Cloning and characterization of a novel human class I histone deacetylase that functions as a transcription repressor. J Biol Chem 275(20) 15254-15264 (2000). Buggy, J.J., Sideris, M.L., Mak, P., et al. Cloning and characterization of a novel human histone deacetylase, HDAC8. Biochem J 350 199-205 (2000). Waltregny, D., Glénisson, W., Tran, S.L., et al. Histone deacetylase HDAC8 associates with smooth muscle a- Nakagawa, M., Oda, Y., Eguchi, T., et al. Expression profile of class I histone deacetylases in human cancer tissues. Oncol Rep 18 769-774 (2007). Show all 13 Hide all but first 3
Description
Human HDAC8 is a class I HDAC and has been identified in a variety of human cancer tissues. Cayman’s HDAC8 Inhibitor Screening Assay provides a convenient fluorescence-
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