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Cat. Number

065965287288079

Chemical Name

Multi-Drug Resistance Assay Kit (Calcein AM)

References

Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere

Background Reading

Manna, J., and Thomas, S.V. Role of multidrug resistance transporters in neurotherapeutics. Ann Indian Acad Neurol 12(2) 89-98 (2009).

Fruttero, R., Crosetti, M., Chegaev, K., et al. Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein. J Med Chem 53 5467-75 (2010).

Polli, J.W., Wring, S.A., Humphreys, J.E., et al. Rational use of in vitro P-glycoprotein assays in drug discovery. J Pharmacol Exp Ther 299(2) 620-8 (2001).

Thomas, H., and Coley, H.M. Overcoming multidrug resistance in cancer: An update on the clinical strategy of inhibiting P-glycoprotein. Cancer Control 10(2) 159-65 (2003).

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600370-1ea
Cell-Based Assay Buffer Tablet	1 ea
Shrimp Kit Box (96 Well)
Cell-Based Assay Calcein AM (1,000X)	1 ea
Cell-Based Assay Hoechst Dye	50 µL
Cell-Based Assay Cyclosporin A	50 µL
Cell-Based Assay Verapamil	50 µL

Size	Global Purchasing
1,000 tests

Description

P-Glycoprotein (P-gp), the product of the multidrug resistance (MDR) gene MDR1, and multidrug resistance associated proteins (MRP) are members of the superfamiliy of ATP-binding cassette (ABC) transporters. They are localized in the luminal membrane of endothelial cells and function to detoxify or eliminate a spectrum of harmful agents and chemicals by mediating energy-dependent transport from the cell. While their expression in normal cells protects the cells from xenobiotic attack, their expression in other cells, such as cancer cells, can be a significant obstacle to drug efficacy. Cayman’s Multidrug Resistance Assay Kit provides a convenient tool for studying MDR protein modulators. The kit employs calcein AM, a substrate for MDR proteins including P-gp and MRP, as a probe for the detection of chemical compounds interacting with MDR proteins. Hoechst Dye is used as a marker of cell nuclei. Cyclosporin A, a competitive inhibitor, and verapamil, a noncompetitive inhibitor, are included as positive controls.

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