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| Cat. Number | L-168,049 |
| Chemical Name | L-168,049 |
| CAS Number | [191034-25-0] |
| Mol. Formula | C24H20BrClN2O |
| Mol. Weight | 467.79 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 4-[3-(5-Bromo-2-propoxyphenyl)-5-(4 -chlorophenyl)-1H-pyrrol-2-yl]pyridine |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| Storage condition | Store at RT |
| References | Very potent and selective, non-competitive antagonist of the human glucagon receptor (hGR). Binds with high affinity to human GR (IC50 = 3.7 nM), and moderate affinity to murine and canine GRs (IC50 values are 63 and 60 nM respectively). In contrast, displays poor affinity for rat, guinea pig, and rabbit glucagon receptors (IC50 > 1 μM). In functional studies, inhibits glucagon-stimulated cAMP synthesis in CHO cells expressing hGR (IC50 = 41 nM), and in murine liver membranes. Orally active in vivo. Purity: >99 % |
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