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| Cat. Number | L189 |
| Chemical Name | L189 |
| CAS Number | [64232-83-3] |
| Mol. Formula | C11H10N4OS |
| Mol. Weight | 246.29 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 6-Amino-2,3-dihydro-5-[(phenylmethy lene)amino]-2-4(1H)-pyrimidineone |
| Solubility | Soluble to 100 mM in DMSO |
| Storage condition | Store at -20°C |
| References | DNA ligase I, III and IV inhibitor (IC50 values are 5, 9 and 5 μM respectively) that blocks DNA binding (Ki = 5 μM for DNA ligase I). Preferentially inhibits step 2 of the ligation reaction, and inhibits base excision repair (BER) and non-homologous end joining (NHEJ). Specifically sensitizes cancer cells to DNA damage and increases the cytotoxicity of DNA-damaging agents. |
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