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| Cat. Number | V0144 |
| Chemical Name | V0144 N-VALERIC ACID 109-52-4 |
| CAS Number | 109-52-4 |
| Mol. Formula | C5H10O2 |
| Mol. Weight | 102.13 |
| Qty 1 |
10ml |
| Qty 2 | 100ml |
| Appearance | Clear and Colorless liquid |
| Application Notes | ≥99% |
| Synonym | Pentanoic acid |
| Solubility | 50mg/ml in water |
| Storage condition | Ambient |
| References | n-Valeric acid is a low molecular weight carboxylic acid with a structure similar to γ-hydroxybutyrate (GHB) and γ-aminobutyric acid (GABA). This compound is found in Valeriana officinalis and is often used in the synthesis of esters. n-Valeric acid may also be produced by intestinal microflora and induces expression of Epstein-Barr virus-associated early antigen and viral capsid antigen in EBV-carrying human lymphoblastoid cells. Additionally, the α-keto-β-methyl derivative of n-valeric acid exhibits antioxidative activity, decreasing reactive oxygen species and lactate dehydrogenase in microglial cells under hypoxic or H2O2-stress-induced conditions. n-Valeric acid may inhibit histone deacetylases (HDAC). ReferencesHuang HM, Ou HC, Chen HL, et al. Protective effect of alpha-keto-beta-methyl-n-valeric acid on BV-2 microglia under hypoxia or oxidative stress. Ann N Y Acad Sci. 2005 May;1042:272-8. PMID: 15965072. Huang HM, Zhang H, Ou HC, et al. alpha-keto-beta-methyl-n-valeric acid diminishes reactive oxygen species and alters endoplasmic reticulum Ca(2+) stores. Free Radic Biol Med. 2004 Dec 1;37(11):1779-89. PMID: 15528037. Midtvedt AC, Midtvedt T. Production of short chain fatty acids by the intestinal microflora during the first 2 years of human life. J Pediatr Gastroenterol Nutr. 1992 Nov;15(4):395-403. PMID: 1469519. |
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