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| Cat. Number | T8006 |
| Chemical Name | T8006 TUBASTATIN A HYDROCHLORIDE 1310693-92-5 |
| CAS Number | 1310693-92-5 |
| Mol. Formula | C20H21N3O2 • HCl |
| Mol. Weight | 371.86 |
| Qty 1 |
1mg |
| Qty 2 | 10mg |
| Appearance | White to off white powder |
| Application Notes | ≥98% |
| Synonym | Tubastatin A HCl |
| Solubility | DMSO 67 mg/mL (199.76 mM) Water Insoluble Ethanol Insoluble |
| Storage condition | -20°C |
| References | Tubastatin A is an inhibitor of class IIb histone deacetylases (HDACs), such as HDAC6 and HDAC10. Tubastatin A exhibits cardioprotective and anticancer chemotherapeutic activities. In vivo, tubastatin A decreases levels of α-tubulin and protects against atrial fibrillation-related atrial remodeling. Additionally, tubastatin A restores expression of primary cilia and decreases cell proliferation and growth in cholangiocarcinoma cells; in similar animal models, this compound inhibits tumor growth. ReferencesZhang D, Wu CT, Qi X, et al. Activation of histone deacetylase-6 induces contractile dysfunction through derailment of α-tubulin proteostasis in experimental and human atrial fibrillation. Circulation. 2014 Jan 21;129(3):346-58. PMID: 24146251. Gradilone SA, Radtke BN, Bogert PS, et al. HDAC6 inhibition restores ciliary expression and decreases tumor growth. Cancer Res. 2013 Apr 1;73(7):2259-70. PMID: 23370327. |
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