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| Cat. Number | 10-4512 |
| Chemical Name | 10-4512 [1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) 118072-93-8 |
| CAS Number | 118072-93-8 |
| Mol. Formula | C5H10N2O7P2 |
| Mol. Weight | 272.09 |
| Qty 1 |
25mg |
| Qty 2 | 100mg |
| Appearance | White or off-white solid |
| Application Notes | 98% by HPLC |
| Synonym | CGP 42446 |
| Solubility | Soluble in Water (up to 2 mg/ml). |
| Storage condition | -20℃ |
| Stability | Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 2 months. |
| References | Zoledronic acid (118072-93-8) is a potent inhibitor of bone resorption (IC50 = 2 nM in mouse calvarial cultures).1 The mechanism of its action is thought to be via inhibition of osteoclastic activity, induction of osteoclast apoptosis and blockage of osteoclastic resorption of mineralized bone and cartilage through its binding to bone. Zoledronic acid is a clinically useful drug for treatment of osteoporosis2, hypercalcemia of malignancy(HCM), multiple myeloma and bone metastases from solid tumors3. It has also been investigated as an antitumor agent and showing efficacy as an adjuvant therapy in several cancers.4,5
References/Citations
Zoledronic acid ，货号10-4512上海惠诚提供25mg 100mg Zoledronic acid，美国focus原装进口，咨询电话021-60498804 Zoledronic acid ，货号10-4512上海惠诚提供25mg 100mg Zoledronic acid，美国focus原装进口，咨询电话021-60498804
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