| Formulation |
200 µl of protein G-purified IgG in 200 µl PBS containing 0.2% gelatin and 0.05% sodium azide |
| Stability |
1 year |
| Storage |
-20°C |
| Shipping |
Wet ice
in continental US; may vary elsewhere
|
| Specificity |
| Murine SET7/9 |
+ |
| Human SET7/9 |
+ |
|
| Size |
Global Purchasing |
| 1 ea |
|
Description
Antigen:
human SET7/9 amino acids 131-145 and 336-352
·
Host:
rabbit
·
Application(s):
WB
·
Diverse signal transduction pathways impinging on the N-terminal tails of histones lead to a number of post-translational modifications including acetylation, phosphorylation, poly(ADP-ribosylation), ubiquitination, and methylation. These modifications play critical roles in regulating chromatin structure and gene expression. Histone methyltransferases (HMTases) selectively methylate evolutionarily conserved arginine or lysine residues, primarily in the N-terminal tails of histones H3 and H4. SET7/9 is a histone specific HMTase that methylates histone H3 lysine 4. SET7/9 transfers methyl groups to lysine 4 of histone H3 in complex with S-adenosyl-L-methionine. Human SET7/9 is a 366 amino acid protein.
