| Stability |
1 year |
| Storage |
-80°C |
| Shipping |
Dry ice
in continental US; may vary elsewhere
|
| Specificity |
| Prostaglandin E1 |
100% |
| Prostaglandin E2 |
100% |
| Prostaglandin F1α |
100% |
| Prostaglandin F2α |
100% |
| Prostaglandin F3α |
51.3% |
| Prostaglandin E2 Ethanolamide |
44.0% |
| 6-keto Prostaglandin F1α |
43.6% |
| 8-iso Prostaglandin F2α |
38.4% |
| 8-iso Prostaglandin E2 |
28.5% |
| Prostaglandin D2 |
26.6% |
| 8-iso-2,3-dinor Prostaglandin F1α |
20.0% |
| Prostaglandin E3 |
9.5% |
| Thromboxane B2 |
5.0% |
| 12(S)-HHTrE |
0.25% |
| Leukotriene D4 |
0.2% |
| Arachidonic Acid |
<0.01% |
| Leukotriene B4 |
<0.01% |
| Leukotriene C4 |
<0.01% |
| Leukotriene E4 |
<0.01% |
| Misoprostol |
<0.01% |
| Misoprostol (free acid) |
<0.01% |
| Prostaglandin A1 |
<0.01% |
| Prostaglandin A2 |
<0.01% |
| Prostaglandin A3 |
<0.01% |
| Prostaglandin B1 |
<0.01% |
| 15-keto Prostaglandin E2 |
<0.01% |
| 13,14-dihydro-15-keto Prostaglandin F2α |
<0.01% |
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|
| Size |
Global Purchasing |
| 96 wells |
|
Description
The COX (ovine) Inhibitor Screening Assay directly measures PGF2α produced in the cyclooxygenase reaction. The prostanoid product is quantified via enzyme immunoassay (EIA) using a broadly specific antibody that binds to all the major prostaglandin compounds. Thus, this Cayman COX assay is more accurate and reliable than an assay based on peroxidase inhibition. The Cayman COX (ovine) Inhibitor Screening Assay includes both ovine COX-1 and COX-2 enzymes in order to screen isozyme-specific inhibitors. This assay is an excellent tool which can be used for general inhibitor screening, or to eliminate false positive leads generated by less specific methods.
