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021-60498804
| Cat. Number | 066102401790289 |
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| Chemical Name | EP4 Receptor (rat) STEP Reporter Assay Kit (Luminescence) |
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| References |
Background ReadingSugimoto, Y., and Narumiya, S. Prostaglandin E receptors. J Biol Chem 282(16) 11613-11617 (2007). Harris, S.G., Padilla, J., Koumas, L., et al. Prostaglandins as modulators of immunity. Trends Immunol 23(3) 144-150 (2002). Sakata, D., Yao, C., and Narumiya, S. Prostaglandin E2, an immunoactivator. J Pharmacol Sci 112 (2010). Ahmad, A.S., Ahmad, M., de Brum-Fernandes, A.J., et al. Prostaglandin EP4 receptor agonist protects against acute neurotoxicity. Brain Res 1066 71-77 (2005). Dey, I., Lejeune, M., and Chadee, K. Prostaglandin E2 receptor distribution and function in the gastrointestinal tract. Br J Pharmacol 149 611-623 (2006). An, S., Yang, J., Xia, M., et al. Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2. Biochem Biophys Res Commun 197 263-270 (1993). Bastien, L., Sawyer, N., Grygorczyk, R., et al. Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype. J Biol Chem 269 11873-11877 (1994). George, R.J., Sturmoski, M.A., Anant, S., et al. EP4 mediates PGE2 dependent cell survival through the PI3 kinase/AKT pathway. Prostaglandins Other Lipid Mediat 83(1-2) 112-120 (2007). Breyer, R.M., Davis, L.S., Nian, C., et al. Cloning and expression of the rabbit prostaglandin EP4 receptor. Am J Physiol 270 F485-F493 (1996). Chell, S.D., Witherden, I.R., Dobson, R.R., et al. Increased EP4 receptor expression in colorectal cancer progression promotes cell growth and anchorage independence. Cancer Res 66(6) 3106-3113 (2006). Show all 10 Hide all but first 3
Description
The EP4 receptor is one of four GPCRs that mediate the actions of prostaglandin E2 (PGE2). The diverse effects of PGE2 acting via EP4 receptors point to the need to identify novel agonists and antagonists, both to further elucidate the function of this receptor subtype and for use as therapeutics for various diseases. Cayman’s EP4 Receptor (rat) STEP Reporter Assay Kit (Luminescence) consists of a 96-
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