Melanocortin-3 Receptor STEP Reporter Assay Kit (Luminescence)_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

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Cat. Number

065991547004009

Chemical Name

Melanocortin-3 Receptor STEP Reporter Assay Kit (Luminescence)

References

Synonyms	MC3R
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere

Background Reading

Chen, A.S., Marsh, D.J., Trumbauer, M.E., et al. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 26 97-102 (2000).

Butler, A.A., Kesterson, R.A., Khong, K., et al. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 141(9) 3518-3521 (2000).

Ni, X., Pearce, D., Butler, A.A., et al. Genetic disruption of γ-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse. J Clin Invest 111(8) 1251-1258 (2003).

Sutton, G.M., Trevaskis, J.L., Hulver, M.W., et al. Diet-genotype interactions in the development of the obese, insulin-resistant phenotype of C57BL/6J mice lacking melanocortin-3 or -4 receptors. Endocrinology 147(5) 2183-2196 (2006).

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600180-1ea
96-Well Solid Plate (black) with lid
Melanocortin-3 Receptor STEP Strip Plate
Melanocortin Assay α-MSH Positive Control	0.01 mL
SEAP Substrate (Luminescence)	15 mL

Size	Global Purchasing
100 tests

Description

The Melanocortin-3 receptor (MC3R) helps regulate energy homeostasis and mice lacking MC3R have increased fat mass and reduced lean mass. Therefore, agonists that selectively activate MC3R might have beneficial effects related to weight gain and glucose metabolism. This assay consists of a 96-well plate coated with both MC3R and Secretory Alkaline Phosphatase (SEAP) reporter constructs. Cells grown on the STEP complex will express MC3R at the cell surface. Binding of agonists to MC3R initiates a signaling cascade resulting in expression of SEAP. SEAP activity is measured following addition of luminescence-based alkaline phosphatase substrate provided in the kit.

下一个：Lysosome/Cytotoxicity Dual Staining Kit上一个：Melanocortin-4 Receptor STEP Reporter Assay Kit (Luminescence)

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