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021-60498804
| Cat. Number | 065945852296297 |
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| Chemical Name | Orexin 2 Receptor STEP Reporter Assay Kit (Luminescence) |
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| References |
Background ReadingThannickal, T.C., Moore, R.Y., Nienhuis, R., et al. Reduced number of hypocretin neurons in human narcolepsy. Neuron 27 469-474 (2000). de Lecea, L., Kilduff, T.S., Peyron, C., et al. The hypocretins: Hypothalamus- Sakurai, T., Amemiya, A., Ishii, M., et al. Orexins and orexin receptors: A family of hypothalamic neuropeptides and G protein- Rodgers, R.J., Ishii, Y., Halford, J.C.G., et al. Orexins and appetite regulation. Neuropeptides 36(5) 303-325 (2002). Xie, X., Wisor, J.P., Hara, J., et al. Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress- Tsujino, N., and Sakurai, T. Orexin/hypocretin: A neuropeptide at the interface of sleep, energy homeostasis, and reward system. Pharmacol Rev 61 162-176 (2009). Harris, G.C., Wimmer, M., and Aston-Jones, G. A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437 556-559 (2005). Show all 7 Hide all but first 3
Description
The Orexin 2 Receptor (OX2R) may be an important therapeutic target for treatment of sleep disorders, obesity, emotional stress, and addiction. Cayman’s Orexin 2 Receptor STEP Reporter Assay Kit (Luminescence) consists of a 96-
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