Leukotriene B4-d4_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

服务热线：13917250134「同微信」

您的位置：首页>>小分子化合物>>Cayman>>Leukotriene B4-d4

产品中心

/ Products Classification 点击展开+

Cat. Number

653021184129385

Chemical Name

Leukotriene B4-d4

References

Synonyms	LTB4-d4
Formal Name	5S,12R-dihydroxy-6Z,8E,10E,14Z-eicosatetraenoic-6,7,14,15-d4 acid
Molecular Formula	C₂₀H₂₈D₄O₄
Formula Weight	340.5
Formulation	A solution in acetonitrile
Purity	≥99% deuterated product
λ_max	270 nm
ε	50
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	CCCCC/C=CC[C@@H](O)/C=C/C=CC=C[C@@H](O)CCCC(=O)O

Background Reading

McMillan, R.M., and Foster, S.J. Leukotriene B₄ and inflammatory disease. Agents Actions 24 114-119 (1988).

McGee, J., and Fitzpatrick, F. Enzymatic hydration of leukotriene A₄. J Biol Chem 260 12832-12837 (1985).

Rådmark, O., Malmsten, C., Samuelsson, B., et al. Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene B. Biochem Biophys Res Commun 92 954-961 (1980).

Ford-Hutchinson, A.W. Leukotriene B₄ in inflammation. Crit Rev Immunol 10 1-12 (1990).

Ford-Hutchinson, A.W., Bray, M.A., Doig, M.V., et al. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286 264-265 (1980).

Show all 5 Hide all but first 3

Size	Global Purchasing
25 µg
50 µg
100 µg
500 µg

Description

Leukotriene B₄-d₄ (LTB₄-d₄) contains four deuterium atoms at the 6, 7, 14, and 15 positions. It is intended for use as an internal standard for the quantification of LTB₄ by GC- or LC-mass spectrometry. LTB₄ is a dihydroxy fatty acid derived from arachidonic acid through the 5-lipoxygenase pathway.^1,2,3 It promotes a number of leukocyte functions including aggregation, stimulation of ion fluxes, enhancement of lysosomal enzyme release, superoxide anion production, chemotaxis, and chemokinesis. In subnanomolar ranges (3.9 x 10⁻¹⁰ M), LTB₄ causes chemotaxis and chemokinesis in human PMNL.⁴ At higher concentrations, (1.0 x 10⁻⁷ M), LTB₄ leads to neutrophil aggregation and degranulation as well as superoxide anion production.^4,5

1 Rådmark, O., Malmsten, C., Samuelsson, B., et al. Leukotriene A: Stereochemistry and enzymatic conversion to leukotriene B. Biochem Biophys Res Commun 92 954-961 (1980).

2 Ford-Hutchinson, A.W., Bray, M.A., Doig, M.V., et al. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286 264-265 (1980).

3 McGee, J., and Fitzpatrick, F. Enzymatic hydration of leukotriene A₄. J Biol Chem 260 12832-12837 (1985).

4 Ford-Hutchinson, A.W. Leukotriene B₄ in inflammation. Crit Rev Immunol 10 1-12 (1990).

5 McMillan, R.M., and Foster, S.J. Leukotriene B₄ and inflammatory disease. Agents Actions 24 114-119 (1988).

下一个：Leukotriene B4 Lipid Maps MS Standard上一个：Latanoprost (free acid)-d4

联系我们

电话：021-60498804
邮箱：info@e-biochem.com
地址：上海市徐汇区漕溪路258弄27号航星商务楼2-404

扫一扫，关注我们

惠诚品牌

产品中心: 分子生物; 分析化学; 生化试剂; 仪器耗材

企业动态

技术资料

在线咨询联系方式二维码

服务热线

021-60498804

扫一扫，关注我们