Latanoprost (free acid)-d4_上海惠诚生物生物试剂,标准品,仪器设备,耗材,一站式服务

服务热线：13917250134「同微信」

您的位置：首页>>小分子化合物>>Cayman>>Latanoprost (free acid)-d4

产品中心

/ Products Classification 点击展开+

Cat. Number

653016613029022

Chemical Name

Latanoprost (free acid)-d4

References

Synonyms	PhXA 85-d4 17-phenyl-13,14-dihydro trinor Prostaglandin F2α-d4 Lat-FA-d4
Formal Name	9α,11α,15R-trihydroxy-17-phenyl-18,19,20-trinor-prost-5Z-en-1-oic-3,3,4,4-d4 acid
Molecular Formula	C₂₃H₃₀D₄O₅
Formula Weight	394.5
Formulation	A solution in methyl acetate
Purity	≥99% deuterated product
Stability	1 year
Storage	-20°C
Shipping	Wet ice in continental US; may vary elsewhere
SMILES	OC(CCc1ccccc1)CC[C@H]1C(O)CC(O)C1C/C=CCCCC(=O)O

Background Reading

Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs Future 17 691-704 (1992).

Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

Sugamoto, K., Matsushita, Y., and Matsui, T. Facile and general method for preparation of (E)-4-hydroxy-2-alkenals. Lipids 32 903-905 (1997).

Camras, C.B., Alm, A., Watson, P., et al. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Ophthalmology 103 1916-1924 (1996).

Show all 4 Hide all but first 3

Size	Global Purchasing
50 µg
100 µg
500 µg
5 mg

Description

Latanoprost (free acid)-d₄ (Lat-FA-d₄) contains four deuterium atoms at the 3, 3, 4, and 4 positions. It is intended for use as an internal standard for the quantification of Lat-FA by GC- or LC-mass spectrometry. Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.¹ It is the isopropyl ester of a PGF_2α analog containing an aromatic group (17-phenyl) in the ω-chain. As an isopropyl ester, latanoprost acts as a prodrug which is converted to Lat-FA by endogenous esterase enzymes. Lat-FA is a potent FP receptor agonist with an EC₅₀ value of 3.6 nM for human FP receptors, which is twice the potency of PGF_2α and more than 200 times more potent latanoprost.² The efficacy of PG analog esters for the treatment of glaucoma correlates closely with the FP receptor binding affinity of the free acid.³ However, Lat-FA is more irritating and less effective than the prodrug latanoprost when applied directly to the eyes of human glaucoma patients.⁴

1 Stjernschantz, J., and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs Future 17 691-704 (1992).

2 Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

3 Camras, C.B., Alm, A., Watson, P., et al. Latanoprost, a prostaglandin analog, for glaucoma therapy. Efficacy and safety after 1 year of treatment in 198 patients. Ophthalmology 103 1916-1924 (1996).

4 Sugamoto, K., Matsushita, Y., and Matsui, T. Facile and general method for preparation of (E)-4-hydroxy-2-alkenals. Lipids 32 903-905 (1997).

下一个：Leukotriene B4-d4上一个：JWH 398-d9

联系我们

电话：021-60498804
邮箱：info@e-biochem.com
地址：上海市徐汇区漕溪路258弄27号航星商务楼2-404

扫一扫，关注我们

惠诚品牌

产品中心: 分子生物; 分析化学; 生化试剂; 仪器耗材

企业动态

技术资料

在线咨询联系方式二维码

服务热线

021-60498804

扫一扫，关注我们