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| Cat. Number | 288104755690404 |
| Chemical Name | AT 101 |
| CAS Number | [90141-22-3] |
| Mol. Formula | C30H30O8 |
| Mol. Weight | 518.56 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | (-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dim ethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8 ,8'-dicarboxaldehyde |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| Storage condition | Store at -20°C |
| References | R-(-)-enantiomer of gossypol (Cat. No. 1964). Mimics the BH3 domains of Bcl-2, Bcl-XL and Mcl-1. Disrupts heterodimerization of Bcl-2 with proapoptotic family members. Induces apoptosis in vitro through activation of caspase-9; cytotoxic to multiple myeloma and drug-resistant cell lines. Delays onset of androgen-independent growth of VCaP prostate cancer xenografts in vivo. Purity: >98 % |
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