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| Cat. Number | 288085736774825 |
| Chemical Name | Astemizole |
| CAS Number | [68844-77-9] |
| Mol. Formula | C28H31FN4O |
| Mol. Weight | 458.57 |
| Qty 1 |
50mg |
| Synonym | 1-[(4-Fluorophenyl)methyl]-N-[1-[2- (4-methoxyphenyl)ethyl]-4-piperidinyl]-1H-benzimid azol-2-amine |
| Solubility | Soluble to 100 mM in DMSO and to 25 mM in ethanol |
| Storage condition | Store at +4°C |
| References | Orally active, potent histamine H1 antagonist (IC50 = 4 nM) that displays 20-fold, > 250-fold and > 250-fold selectivity over 5-HT, dopamine and muscarinic acetylcholine receptors respectively. Exhibits antimalarial activity in multidrug resistant strains in vitro (IC50 = 227 - 734 nM). Also potent hERG K+ channel blocker (IC50 = 0.9 nM) that displays cardiotoxicity in vivo. Purity: >99 % |
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