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| Cat. Number | 286126437371824 |
| Chemical Name | A 83-01 |
| CAS Number | [909910-43-6] |
| Mol. Formula | C25H19N5S |
| Mol. Weight | 421.52 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 3-(6-Methyl-2-pyridinyl)-N-phenyl-4 -(4-quinolinyl)-1H-pyrazole-1-carbothioamide |
| Solubility | Soluble to 50 mM in DMSO |
| Storage condition | Store at -20°C |
| References | Selective inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542 (Cat.No. 1614). Inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs. Purity: >98 % |
下一个：A 841720上一个：A 80426 mesylate |
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