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| Cat. Number | 282629597264212 |
| Chemical Name | CGP 57380 |
| CAS Number | [522629-08-9] |
| Mol. Formula | C11H9FN6 |
| Mol. Weight | 244.23 |
| Qty 1 |
1mg |
| Qty 2 | 50mg |
| Synonym | N3-(4-Fluorophenyl)-1H-pyrazolo-[3, 4-d]pyrimidine-3,4-diamine |
| Solubility | Soluble to 100 mM in DMSO |
| Storage condition | Store at +4°C |
| References | Inhibitor of MAP-kinase interacting kinase-1 (Mnk1, MKNK1) (IC50 = 2.2 μM) that displays selectivity over p38, JNK1, ERK1, ERK2, PKC and c-src family kinases. Blocks phosphorylation of eIF4E in cellular assays (IC50 = 3 μM) and inhibits LPS-induced TNFα expression in macrophages. Purity: >98 % |
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