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| Cat. Number | 279634359956408 |
| Chemical Name | (R)-DRF053 dihydrochloride |
| CAS Number | [1056016-06-8] |
| Mol. Formula | C23H27N7O.2HCl |
| Mol. Weight | 490.43 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 2-[[9-(1-Methylethyl)-6-[[3-(2-pyri dinyl)phenyl]amino]-9H-purin-2-yl]amino]-1-butanol dihydrochloride |
| Solubility | Soluble to 100 mM in water and to 100 mM in DMSO |
| Storage condition | Store at +4°C |
| References | Potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively). Selective over GSK-3 αβ (IC50= 4.1 μM). Also shown to inhibit amyloid-β production in N2A-APP695 cells. Purity: >98 % |
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