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| Cat. Number | Go 6976 |
| Chemical Name | Go 6976 |
| CAS Number | [136194-77-9] |
| Mol. Formula | C24H18N4O |
| Mol. Weight | 378.43 |
| Qty 1 |
1mg |
| Synonym | 5,6,7,13-Tetrahydro-13-methyl-5-oxo -12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propa nenitrile |
| Solubility | Soluble in DMSO |
| Storage condition | Desiccate at -20°C |
| References | Potent protein kinase C (PKC) inhibitor (IC50 = 7.9 nM). Discriminates between Ca2+-dependent and -independent isoforms of PKC in vitro; selectively inhibits PKCα and PKCβ1 (IC50 values are 2.3 and 6.2 nM respectively). Does not inhibit the activity of PKCδ, -ε, or -ζ (IC50 > 3μM). Also inhibits TrkA, TrkB, JAK2 and JAK3 tyrosine kinases (IC50 values are 5, 30, 130 and 370 nM respectively), PKCμ (PKD1) and the mitotic spindle checkpoint. Purity: >99 % |
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