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| Cat. Number | Gambogic acid |
| Chemical Name | Gambogic acid |
| CAS Number | [2752-65-0] |
| Mol. Formula | C38H44O8 |
| Mol. Weight | 628.75 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | (2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14a S)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl- 13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7 ,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[ 3,2-b]xanthen-1-yl]-2-butenoic acid |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| Storage condition | Store at -20°C |
| References | Natural product isolated from the Garcinia hanburyi tree. Induces apoptosis in several tumor cell lines including T47D cells. Activates caspases with an EC50 value of 0.78 - 1.64 μM and competitively inhibits antiapoptotic Bcl-2 family proteins (IC50 values are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 respectively). Also blocks KIR2.1 channels (EC50 ≤ 100 nM). |
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