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Cat. Number
HDS 029
Chemical Name
HDS 029
Mol. Formula
C17H11ClFN5O
Mol. Weight
355.76
Qty 1
1mg
Qty 2
10mg
Synonym
N-(4-[(-3-Chloro-4-fluorophenyl)ami no]pyrido[3,4-d]pyrimidin-6-yl-2-butynamide
Solubility
Soluble to 25 mM in DMSO
Storage condition
Store at -20°C
References
Potent inhibitor of the ErbB receptor family (IC50 values are 0.3, 0.5 and 1.1 nM for ErbB1 (EGFR), ErbB4 and ErbB2 respectively). Inhibits EGF-induced erbB1 autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells (IC50 values are 2.5 and 24 nM respectively).
Purity: >97 %
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