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| Cat. Number | JNJ 16259685 |
| Chemical Name | JNJ 16259685 |
| CAS Number | [409345-29-5] |
| Mol. Formula | C20H23NO3 |
| Mol. Weight | 325.41 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | (3,4-Dihydro-2H-pyrano[2,3-b]quinol in-7-yl)-(cis-4-methoxycyclohexyl)-methanone |
| Solubility | Soluble to 100 mM in ethanol and to 25 mM in DMSO |
| Storage condition | Store at +4°C |
| References | Sub-nanomolar potent, non-competitive mGlu1 antagonist (Ki = 0.34 nM). Inhibits glutamate-induced Ca2+ response at the human mGlu1 receptor with an IC50 value of 0.55 nM. Selective over mGlu5 (> 400-fold) and displays no activity at mGlu2, mGlu3, mGlu4, mGlu6, AMPA or NMDA receptors (IC50 > 10 μM). Centrally active following systemic administration. Purity: >98 % |
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