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| Cat. Number | LY 393558 |
| Chemical Name | LY 393558 |
| CAS Number | [271780-64-4] |
| Mol. Formula | C26H31FN4O4S2 |
| Mol. Weight | 546.68 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 1-[2-[4-(6-Fluoro-1H-indol-3-yl)-3, 6-dihydro-1(2H)-pyridinyl]ethyl]-3,4-dihydro-3-(1- methylethyl)-6-(methylsulfonyl)-1H-2,1,3-benzothia diazine-2,2-dioxide |
| Solubility | Soluble to 100 mM in DMSO |
| Storage condition | Store at +4°C |
| References | Dual 5-HT1B/1D receptor antagonist (pKB values are 9.05 and 8.98 respectively) and 5-HT re-uptake inhibitor (pIC50 = 8.48). Potently antagonizes terminal autoreceptor activity in vitro and increases extracellular 5-HT levels above those evoked by fluoxetine (Cat. No. 0927) in vivo. Also acts as an antagonist at 5-HT2A and 5-HT2B receptors (pKi values are 7.29 and 7.35 respectively). Purity: >98 % |
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