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Cat. Number
LY 379268
Chemical Name
LY 379268
CAS Number
[191471-52-0]
Mol. Formula
C7H9NO5
Mol. Weight
187.15
Qty 1
10mg
Qty 2
50mg
Synonym
(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[ 3.1.0]hexane-4,6-dicarboxylic acid
Solubility
Soluble to 20 mM in water and to 100 mM in 1eq. NaOH
Storage condition
Store at +4°C
References
Highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active. Caged LY 379268 is also available (Cat. No. 3332).
Purity: >99 %
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