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| Cat. Number | SP 600125 |
| Chemical Name | SP 600125 |
| CAS Number | [129-56-6] |
| Mol. Formula | C14H8N2O |
| Mol. Weight | 220.23 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | Anthra[1-9-cd]pyrazol-6(2H)-one |
| Solubility | Soluble to 10 mM in ethanol and to 100 mM in DMSO |
| Storage condition | Desiccate at -20°C |
| References | Selective inhibitor of c-Jun N-terminal kinase (JNK). Competitively and reversibly inhibits JNK1, 2 and 3 (IC50 = 40 - 90 nM) with negligible activity at ERK2, p38β and a range of enzymes (IC50 > 10 μM). Active in vivo. Shown to have reduced selectivity over other protein kinases under certain conditions. Protects renal tubular epithelial cells against ischemia/reperfusion-induced apoptosis. Also available as part of the MAPK Inhibitor Tocriset™. Purity: >98 % |
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