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| Cat. Number | PHA 767491 hydrochloride |
| Chemical Name | PHA 767491 hydrochloride |
| CAS Number | [845714-00-3] |
| Mol. Formula | C12H11N3O.HCl |
| Mol. Weight | 249.7 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 1,5,6,7-Tetrahydro-2-(4-pyridinyl)- 4H-pyrrolo[3,2-c]pyridin-4-one hydrochloride |
| Solubility | Soluble to 100 mM in water and to 100 mM in DMSO |
| Storage condition | Desiccate at RT |
| References | Potent, ATP-competitive dual cdc7/cdk9 inhibitor (IC50 values are 10 and 34 nM respectively) that prevents initiation of DNA replication. Inhibits cell proliferation in a variety of human cell lines (IC50 ~ 0.86 - 5.87 μM) and induces apoptosis in a p53-independent manner in vivo. Also inhibits mitogen-activated protein kinase-activated protein kinase-2 (MK-2) (IC50 = 171 nM). Purity: >99 % |
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