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| Cat. Number | PHA 665752 |
| Chemical Name | PHA 665752 |
| CAS Number | [477575-56-7] |
| Mol. Formula | C32H34Cl2N4O4S |
| Mol. Weight | 641.61 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | (2R)-1-[[5-[(Z)-[5-[[(2,6-Dichlorop henyl)methyl]sulfonyl]-1,2-dihydro-2-oxo-3H-indol- 3-ylidene]methyl]-2,4-dimethyl-1H-pyrrol-3-yl]carb onyl]-2-(1-pyrrolidinylmethyl)pyrrolidine |
| Solubility | Soluble to 100 mM in DMSO |
| Storage condition | Store at +4°C |
| References | Potent, selective and ATP-competitive inhibitor of MET kinase (IC50 values are 9, 68, 200, 1400, 3000, 3800 and 6000 nM for MET, Ron, Flk-1, c-abl, FGFR1, EGFR and c-src respectively and > 10000 nM for IGF-IR, PDGFR, AURORA2, PKA, PKBα, p38α, MK2 and MK3). Antitumor agent; inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts. Purity: >98 % |
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