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| Cat. Number | PF 670462 |
| Chemical Name | PF 670462 |
| CAS Number | [950912-80-8] |
| Mol. Formula | C19H20FN5.2HCl |
| Mol. Weight | 410.32 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 4-[1-Cyclohexyl-4-(4-fluorophenyl)- 1H-imidazol-5-yl]-2-pyrimidinamine dihydrochloride |
| Solubility | Soluble to 100 mM in water and to 100 mM in DMSO |
| Storage condition | Desiccate at RT |
| References | Potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo. Purity: >99 % |
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