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| Cat. Number | PD 98059 |
| Chemical Name | PD 98059 |
| CAS Number | [167869-21-8] |
| Mol. Formula | C16H13NO3 |
| Mol. Weight | 267.28 |
| Qty 1 |
1mg |
| Qty 2 | 50mg |
| Synonym | 2-(2-Amino-3-methoxyphenyl)-4H-1-be nzopyran-4-one |
| Solubility | Soluble to 25 mM in DMSO and to 5 mM in ethanol |
| Storage condition | Store at RT |
| References | Specific inhibitor of mitogen-activated protein kinase kinase (MAPKK / MEK). Acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7 μM). Inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G1 arrest by blocking p53-dependent p21 induction. Also available as part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™. Purity: >99 % |
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