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| Cat. Number | PD 198306 |
| Chemical Name | PD 198306 |
| CAS Number | [212631-61-3] |
| Mol. Formula | C18H16F3IN2O2 |
| Mol. Weight | 476.23 |
| Qty 1 |
10mg |
| Synonym | N-(Cyclopropylmethoxy)-3,4,5-triflu oro-2-[(4-iodo-2-methylphenyl)amino]-benzamide |
| Solubility | Soluble to 100 mM in DMSO and to 100 mM in ethanol |
| Storage condition | Store at +4°C |
| References | Potent inhibitor of MEK1/2. Inhibits isolated enzyme at a concentration of 8 nM and inhibits MEK activity in synovial fibroblasts at concentrations of 30 - 100 nM. Highly selective for MEK; IC50 values are > 1, > 4, > 4 and > 10 μM for ERK, c-Src, cdks and PI 3-kinase γ respectively. Antihyperalgesic; blocks static allodynia in the streptozocin model of neuropathic pain following i.t. administration. Purity: >98 % |
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