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| Cat. Number | Ro 3306 |
| Chemical Name | Ro 3306 |
| CAS Number | [872573-93-8] |
| Mol. Formula | C18H13N3OS2 |
| Mol. Weight | 351.45 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 5-(6-Quinolinylmethylene)-2-[(2-thi enylmethyl)amino]-4(5H)-thiazolone |
| Solubility | Soluble to 50 mM in DMSO |
| Storage condition | Store at +4°C |
| References | ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor (Ki values are 35 and 110 nM for cdk1/cyclin B1 and cdk1/cyclin A respectively). Induces G2/M phase cell cycle arrest and apoptosis. Downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML). Purity: >98 % |
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