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| Cat. Number | SC 514 |
| Chemical Name | SC 514 |
| CAS Number | [354812-17-2] |
| Mol. Formula | C9H8N2OS2 |
| Mol. Weight | 224.3 |
| Qty 1 |
10mg |
| Qty 2 | 50mg |
| Synonym | 4-Amino-[2',3'-bithiophene]-5-carboxa mide |
| Solubility | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| Storage condition | Store at +4°C |
| References | Orally active, ATP-competitive IKK-2 inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK. Attenuates NF-κB-induced gene expression of IL-6, IL-8 and COX-2 in synovial fibroblasts (IC50 values are 20, 20 and 8 μM respectively). Reduces iNOS induction and exhibits anti-inflammatory activity in vivo. Purity: >98 % |
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