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| Cat. Number | SB 218078 |
| Chemical Name | SB 218078 |
| CAS Number | [135897-06-2] |
| Mol. Formula | C24H15N3O3 |
| Mol. Weight | 393.39 |
| Qty 1 |
1mg |
| Qty 2 | 10mg |
| Synonym | 9,10,11,12-Tetrahydro- 9,12-epoxy-1H-diindolo[1,2,3-fg:3',2 ',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-1,3(2H)-di one |
| Solubility | Soluble to 100 mM in DMSO |
| Storage condition | Store at RT |
| References | Inhibitor of checkpoint kinase 1 (Chk1) that displays selectivity over other protein kinases (IC50 values are 15, 250 and 1000 nM for Chk1, cdc2 and PKC respectively). Abrogates G2 cell cycle arrest caused by γ-irradiation and topoisomerase I inhibition. Potentiates cytotoxicity of DNA-damaging drugs, enhancing the efficacy of some chemotherapeutics. Purity: >98 % |
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