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| Cat. Number | SB 203580 |
| Chemical Name | SB 203580 |
| CAS Number | [152121-47-6] |
| Mol. Formula | C21H16FN3OS |
| Mol. Weight | 377.44 |
| Qty 1 |
1mg |
| Qty 2 | 50mg |
| Synonym | 4-[5-(4-Fluorophenyl)-2-[4-(methyls ulfonyl)phenyl]-1H-imidazol-4-yl]pyridine |
| Solubility | Soluble to 25 mM in DMSO and to 100 mM in 1eq. HCl |
| Storage condition | Desiccate at +4°C |
| References | Selective inhibitor of p38 mitogen-activated protein kinase (IC50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38β2 respectively). Displays 100-500-fold selectivity over LCK, GSK-3β and PKBα. Shown to inhibit interleukin-2-induced T-cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase. Enhances clonal growth of skin epithelial progenitor cells; stimulates neural stem cell (NSC) proliferation. Part of the MAPK Cascade Inhibitor Tocriset™ and MAPK Inhibitor Tocriset™. Water-soluble salt SB 203580 hydrochloride (Cat. No. 1402) also available. Purity: >98 % |
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