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Cat. Number
733983394799923
Chemical Name
Nitisinone
CAS Number
104206-65-7
Category
Aromatics, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Mol. Formula
C14H10F3NO5
Mol. Weight
329.23
Qty 1
10mg
Qty 2
100mg
Appearance
Light Brown Solid
Application Notes
Herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I.
Synonym
2-[2-Nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedione; NTBC; Nitisone; Orfadin; SC 0735;
Melting Pt.
129-131°C
Solubility
Chloroform, Ethyl Acetate
Storage condition
-20?C Freezer
References
Lindstedt, S., et al.: Lancet, 340, 813 (1992), Ellis, M.K., et al.: Toxicol. Appl. Pharmacol., 133, 12 (1995), Lock, E.A., et al.: J. Inherited Metab. Dis., 21, 498 (1998),
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