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Cat. Number
733976400777639
Chemical Name
埃博霉素 Epothilone B
CAS Number
152044-54-7
Category
Chiral Reagents, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
Mol. Formula
C27H41NO6S
Mol. Weight
507.68
Qty 1
1mg
Qty 2
10mg
Appearance
White Powder
Synonym
(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione; (-)-Epothilone B; EPO 906; EPO 906A; Epothilone B; Patupilone;
Melting Pt.
95-97°C
Solubility
Chloroform, Dichloromethane, DMSO, Ethanol, Methanol
Storage condition
-20°C
References

Bollag, D.M., et al.: Cancer. Res., 55, 2325 (1995),
Hardt, I.H., et al.: J. Nat. Prod., 64, 847 (2001),
Gerth, K., et al.: J. Antibiot., 55, 41, 45 (2002)

The epothilones are cytotoxic agents from the common soil bacteria Sorangium cellulosum. They have taxol like mechanism as microtubule stabilizers binding to beta tubulin. The cytotoxity of epothilone B was found to be superior than that of taxol.
Soluble in DMSO (≥102mg/mL) and Ethanol (≥102mg/mL). Practically insoluble in Water (<1mg/mL).

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