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Cat. Number
733974316544808
Chemical Name
N-Desmethyl Imatinib-d8
Category
Isotope Labelled Compounds, Metabolites, Pharmaceuticals, Intermediates & Fine Chemicals, Tyrosine Kinase Inhibitors,
Mol. Formula
C28H21D8N7O
Mol. Weight
487.63
Qty 1
0.25mg
Qty 2
2.5mg
Appearance
Yellow Solid
Application Notes
A deuterated metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL).
Synonym
N-Desmethyl Gleevec-d8
Melting Pt.
97-103°C
Solubility
Chloroform, Dichloromethane
References

Schindler, T., et al.: Science, 289, 1938 (2000),
Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001),

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