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鞘磷脂、脑苷脂以及神经节苷脂系列同位素标记简介
鞘脂是一类含有鞘氨醇骨架的两性脂，是仅次于磷脂的第二大类膜脂。鞘脂一端连接着一个长链的脂肪酸，另一端为一个极性的醇。鞘脂正常代谢的维持不仅是细胞生存的关键，也对包括抗病免疫调控、植物育性等在内的发育过程，有着十分重要的作用。丝氨酸棕榈酰转移酶（Serine palmitoyltransferase, SPT）是催化鞘脂合成的第一步，同时也是关键的限速步骤。在人和酵母中，类黏膜蛋白（Orosomucoid, ORM）通过负调控SPT酶来维持细胞内的鞘脂稳态。稳定的同位素标准可以很容易地检测到质谱，同时相比天然鞘脂显示出几乎相同的物理性质,这对于确保分析物和内部标准物之间具有相似的提取特性和信号响应非常重要。
鞘脂包括鞘磷脂、脑苷脂以及神经节苷脂，一般存在于植物和动物膜内，尤其是在中枢神经系统的组织内含量丰富。又称鞘磷脂、鞘氨醇磷脂或神经磷脂·由鞘氨醇、脂肪酸与磷酰胆碱组成的分子，它是鞘磷脂类的典型代表，在高等动物的组织中含量极为丰富。鞘脂作为信号分子在植物生长和胁迫过程中扮演着重要的角色。
With the availability of stable isotope standards and the incorporation of soft ionization techniques in mass spectrometry the detection of very small amounts of sphingolipids can be accomplished. The two major approaches of sphingolipidomic studies are the liquid chromatography-mass spectrometry based methods and the shotgun lipidomics approach.These techniques require the use of internal standards for each class of sphingolipid expected to be found in a sample. Stable isotope standards can be easily detected by mass spectrometry while demonstrating nearly identical physical properties as compared to natural sphingolipids. This is very important to ensure similar extraction properties and signal response between the analytes and the internal standards.
Synonym:15,15,16,16,17,17,18,18,18-D9-2-Amino-octadec-4-ene-1,3-diol;
N-omega-CD3-Octadecanoyl-D-erythro-sphingosine 1 mg
N-(32-Linoleoyloxy-dotriacontanoyl)-sphingosine-D9 1 mg
N-omega-CD3-Octadecanoyl-D-erythro-dihydrosphingosine 1 mg
N-1-13C-Hexadecanoyl-D-erythro-sphingosylphosphorylcholine 1mg
N-Octadecanoyl-D3-D-erythro-sphingosine-1-phosphate, deuterated 1 mg $
N-Octadecanoyl-D35-psychosine, (perdeuterated, C18:0 fatty acid) 5 mg
N-omega-CD3-Hexadecanoyl-glucopsychosine 1 mg
N-omega-CD3-Octadecanoyl-sulfatide 1 mg
N-omega-CD3-Hexadecanoyl-lactosylceramide 1 mg
N-omega-CD3-Octadecanoyl-ceramide trihexoside 500 µg
N-omega-CD3-Octadecanoyl monosialoganglioside GM1 (NH4+ salt) 500 µg
N-omega-CD3-Octadecanoyl monosialoganglioside GM2 (NH4+ salt) 250 ug
N-omega-CD3-Octadecanoyl monosialoganglioside GM3 (NH4+ salt) 250 ug
N-omega-CD3-Octadecanoyl disialoganglioside GD3 500 µg
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