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| Cat. Number | T6933 |
| Chemical Name | T6933 TRICHOSTATIN A 58880-19-6 |
| CAS Number | 58880-19-6 |
| Mol. Formula | C17H22N2O3 |
| Mol. Weight | 302.37 |
| Qty 1 |
1mg |
| Qty 2 | 5mg |
| Appearance | Beige Powder |
| Application Notes | ≥98% |
| Synonym | TSA |
| Melting Pt. | 150-151°C |
| Solubility | Soluble in lower alchols. Slightly soluble in chloroform, ethyl acetate, acetone and benzene. |
| Storage condition | -20°C |
| References | Trichostatin A is an inhibitor of class I and II HDACs that exhibits anticancer and immunomodulatory activities. Trichostatin A induces cell cycle arrest, increases phosphorylation of JNK, downregulates activity of MCM-2, induces apoptosis, and inhibits proliferation of colon cancer cells. Trichostatin A also enhances differentiation and activity of CD4+ Foxp3+ Treg cells. Additionally, trichostatin A alters mammalian RNA splicing. Trichostatin A also alters RNA splicing. References Liu Y, He G, Wang Y, et al. MCM-2 is a therapeutic target of Trichostatin A in colon cancer cells. Toxicol Lett. 2013 Jul 31;221(1):23-30. PMID: 23770000. Doñas C, Fritz M, Manríquez V, et al. Trichostatin A promotes the generation and suppressive functions of regulatory T cells. Clin Dev Immunol. 2013;2013:679804. PMID: 23737814. Cecconi D, Donadelli M, Rinalducci S,et al. Proteomic analysis of pancreatic endocrine tumor cell lines treated with the histone deacetylase inhibitor trichostatin A. Proteomics. 2007 May;7(10):1644-53. PMID: 17443844. |
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