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| Cat. Number | E6396 |
| Chemical Name | E6396 EPZ005687 1396772-26-1 |
| CAS Number | 1396772-26-1 |
| Mol. Formula | C32H37N5O3 |
| Mol. Weight | 539.67 |
| Qty 1 |
1mg |
| Qty 2 | 100mg |
| Appearance | white powder |
| Application Notes | ≥99% |
| Solubility | DMSO 2 mg/mL (3.7 mM) Water Insoluble Ethanol Insoluble |
| Storage condition | -20°C |
| References | EPZ-005687 is a highly selective inhibitor of mutant EZH2, a histone methyltransferase (HMT) that exhibits point mutations at key residues Tyr641 and Ala677 in non-Hodgkin’s lymphoma and other cancers. EPZ-005687 displays anticancer chemotherapeutic activity through its inhibition of EZH2; this enzyme is responsible for methylation of lysine and arginine residues and controls gene transcription fidelity in cells. Inhibition of mutant EZH2 induces apoptosis. ReferencesKnutson SK, Wigle TJ, Warholic NM, et al. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol. 2012 Nov;8(11):890-6. PMID: 23023262. |
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