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| Cat. Number | M3476 |
| Chemical Name | M3476 MITHRAMYCIN 18378-89-7 |
| CAS Number | 18378-89-7 |
| Mol. Formula | C52H76O25 |
| Mol. Weight | 1084.47 |
| Qty 1 |
1mg |
| Qty 2 | 10mg |
| Appearance | Yellow Powder |
| Application Notes | ≥98% |
| Synonym | Plicamycin, Mithramycin A |
| Melting Pt. | 175-180°C |
| Solubility | DMSO (20 mg/ml), Methanol, Ethanol (10 mg/ml) |
| Storage condition | 4°C |
| References | Mithramycin is an aureolic acid-type polyketide antibiotic initially produced by species of Streptomyces. Mithramycin exhibits neuroprotective and anticancer chemotherapeutic activities. In animal models of Huntington’s disease, mithramycin prevented increases in H3 histone methylation, delaying disease pathology, improving motor performance, and increasing survival rates. Mithramycin is a reversible inhibitor of RNA synthesis, binding CG and GC sequences and inhibiting transcription initiation. Mithramycin also inhibits CpG methylation of tumor-suppressor genes through direct inhibition of DNA methyltransferase 1 (DNMT1) activity in lung cancer cells. In cellular and animal models of prostate cancer, mithramycin increases levels of tBid and decreases levels of mTOR and Mcl-1, inducing apoptosis and inhibiting tumor growth. ReferencesChoi ES, Chung T, Kim JS, et al. Mithramycin A induces apoptosis by regulating the mTOR/Mcl-1/tBid pathway in androgen-independent prostate cancer cells. J Clin Biochem Nutr. 2013 Sep;53(2):89-93. PMID: 24062605. Choi ES, Jung JY, Lee JS, et al. Myeloid cell leukemia-1 is a key molecular target for mithramycin A-induced apoptosis in androgen-independent prostate cancer cells and a tumor xenograft animal model. Cancer Lett. 2013 Jan 1;328(1):65-72. PMID: 23000424. Lin RK, Hsu CH, Wang YC. Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells. Anticancer Drugs. 2007 Nov;18(10):1157-64. PMID: 17893516. Ferrante RJ, Ryu H, Kubilus JK, et al. Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease. J Neurosci. 2004 Nov 17;24(46):10335-42. PMID: 15548647. Miller DM, Polansky DA, Thomas SD, et al. Mithramycin selectively inhibits transcription of G-C containing DNA. Am J Med Sci. 1987 Nov;294(5):388-94. PMID: 2962490. |
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